Viral trigger for diabetes?
نویسندگان
چکیده
منابع مشابه
Viral Trigger for Type 1 Diabetes
The most popular hypothesis circulating within and beyond the scientific community is that viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can injure -cells and have been isolated in pancreatic tissues from diabetic patients. However, accumulating evidence suggests that the opposite scenario, which is prevention or amelioration of type 1 diabetes...
متن کاملDiabetes and Viral Infection
Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of β cells [1]. Beside genetic factors, environmental factors such as viruses have been reported to be associated with T1D in human. These viruses include Rubella virus and cytomegalo virus [2,3], coxsackieviruses [4], mumps virus [5], Epstein-Barr virus [6,7], varicella zostar virus [8], rotavirus [9], H1N1 influenza v...
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In neonatal rodents, the -cell mass undergoes a phase of remodeling that includes a wave of apoptosis. Using both mathematical modeling and histochemical detection methods, we have demonstrated that -cell apoptosis is significantly increased in neonates as compared with adult rats, peaking at ~2 weeks of age. Other tissues, including the kidney and nervous system, also exhibit neonatal waves of...
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Sera from 123 patients with diabetes mellitus of recent onset, 155 patients with diabetes of more than two years' duration, and 250 normal persons were collected over a period of two and a half years. All sera were tested for neutralizing antibody to Coxsackie virus types B1-6, and a sample was tested for complement-fixing antibody to a number of viral, rickettsial, and mycoplasmal antigens.In ...
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Type 1 diabetes mellitus (T1DM) is an autoimmune disease. The etiology of T1DM is incompletely understood but environmental agent(s) are thought to trigger T1DM in the genetically at risk. Exposure to cow's milk early in life is a recognized risk factor in the development of T1DM. Mycobacterium avium ss. paratuberculosis (MAP) is the cause of bovine Johne's disease and also is thought to act as...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2009
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri2539